Clues for the word "OPERATE"

We've had 65 crossword clues used for this word, and seen it 187 times in crosswords. It was last seen in Daily Cryptic crossword on June 08, 2026.

Definition of operate

v. i. - To perform a work or labor; to exert power or strengh, physical or mechanical; to act.
v. i. - To produce an appropriate physical effect; to issue in the result designed by nature; especially (Med.), to take appropriate effect on the human system.
v. i. - To act or produce effect on the mind; to exert moral power or influence.
v. i. - To perform some manual act upon a human body in a methodical manner, and usually with instruments, with a view to restore soundness or health, as in amputation, lithotomy, etc.
v. i. - To deal in stocks or any commodity with a view to speculative profits.
v. t. - To produce, as an effect; to cause.
v. t. - To put into, or to continue in, operation or activity; to work; as, to operate a machine.