Related Clues

• Major annoyance
• Problem
• Annoying situation
• Annoyance
• Cephalalgia
• Pain in the brain
• Nuisance
• Aspirin target
• One reason for taking aspirin
• Ibuprofen target
• Major inconvenience
• Big pain
• Big bother
• Migraine, for one
• Vexatious problem
• Bother
• Migraine
• Big problem
• Vexing situation
• Bothersome type