Related Clues

• Fret
• Dog or hound
• "What, me ___?"
• Cause of wrinkles
• Trouble
• "What, me ___?" (Mad magazine motto)
• Cause of fitful sleep
• It "often gives a small thing a big shadow": old proverb
• Stew
• Anxiety
• "Interest paid on trouble before it falls due," per W. R. Inge
• Be fretful
• Lose sleep over (with "about")
• "What, me ___?": Alfred E. Neuman line
• Concern
• See 7-Down
• End of Alfred E. Neuman's slogan
• Feel uneasy
• Be in a fretful mood
• Producer of wrinkles, it's said